This Delegation’s remit covers relations with the four countries of Mercosur: Argentina, Brazil, Paraguay and Uruguay. Pending ratification of Venezuela's accession to Mercosur, the relations with Venezuela are covered by the Delegation for relations with the countries of the Andean Community in cooperation with the Delegation for relations with the Mercosur countries.
Every year, the Members of the Delegation visit the region and receive visits from members of the national parliaments from the Mercosur countries and from the Mercosur Parliament (Parlasur). The Members of the Delegation are also Members of the EuroLat Parliamentary Assembly and meet their Mercosur counterparts also on the occasion of the Assembly's activities.